Description
Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 = 1.5, 5.9 and 22.3 µM, respectively), displaying no significant inhibitory effects on UCH-L3, USP2, and USP8 activity. Vialinin A has been shown to reduce the release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells